Schizophrenia/Psychosis

What is Schizophrenia?

Schizophrenia is a chronic brain disorder that affects less than 1% of the U.S. population. When schizophrenia is active, symptoms can include delusions, hallucinations, disorganized speech, trouble with thinking, and lack of motivation. However, with treatment, most symptoms of schizophrenia will greatly improve, and the likelihood of a recurrence can be diminished.

While there is no cure for schizophrenia, research is leading to innovative and safer treatments. Experts are also unravelling the causes of the disease by studying genetics, conducting behavioural research, and using advanced imaging to look at the brain’s structure and function. These approaches hold the promise of new and more effective therapies.

The complexity of schizophrenia may help explain why there are misconceptions about the disease. Schizophrenia does not mean split personality or multiple-personality. Most people with schizophrenia are not any more dangerous or violent than people in the general population. While limited mental health resources in the community may lead to homelessness and frequent hospitalizations, it is a misconception that people with schizophrenia end up homeless or living in hospitals. Most people with schizophrenia live with their family, in group homes, or on their own.

Research has shown that schizophrenia affects men and women fairly equally but may have an earlier onset in males. Rates are similar around the world. People with schizophrenia are more likely to die younger than the general population, largely because of high rates of co-occurring medical conditions, such as heart disease and diabetes.

Definitions
  • Psychosis refers to a set of symptoms characterized by a loss of touch with reality due to a disruption in the way that the brain processes information. When someone experiences a psychotic episode, the person’s thoughts and perceptions are disturbed, and the individual may have difficulty understanding what is real and what is not.
  • Delusions are fixed false beliefs held despite clear or reasonable evidence that they are not true. Persecutory (or paranoid) delusions, when a person believes they are being harmed or harassed by another person or group, are the most common.
  • Hallucinations are the experience of hearing, seeing, smelling, tasting, or feeling things that are not there. They are vivid and clear, with an impression similar to normal perceptions. Auditory hallucinations, “hearing voices,” are the most common in schizophrenia and related disorders.
  • Disorganized thinking and speech refer to thoughts and speech that are jumbled and do not make sense. For example, the person may switch from one topic to another or respond with an unrelated topic in conversation. The symptoms are severe enough to cause substantial problems with normal communication.
  • Disorganized or abnormal motor behaviours are movements that can range from childlike silliness to unpredictable agitation or can manifest as repeated movements without purpose. When the behaviour is severe, it can cause problems in the performance of activities of daily life. It includes catatonia, when a person appears as if in a daze with little movement or response to the surrounding environment.

Negative symptoms refer to what is abnormally lacking or absent in the person with a psychotic disorder. Examples include impaired emotional expression, decreased speech output, reduced desire to have social contact or to engage in daily activities, and decreased experience of pleasure.

Symptoms

When the disease is active, it can be characterized by episodes in which the person is unable to distinguish between real and unreal experiences. As with any illness, the severity, duration, and frequency of symptoms can vary; however, in persons with schizophrenia, the incidence of severe psychotic symptoms often decreases as the person becomes older. Not taking medications as prescribed, the use of alcohol or illicit drugs, and stressful situations tend to increase symptoms. Symptoms fall into three major categories:

  • Positive symptoms: (those abnormally present) Hallucinations, such as hearing voices or seeing things that do not exist, paranoia, and exaggerated or distorted perceptions, beliefs, and behaviours.
  • Negative symptoms: (those abnormally absent) A loss or a decrease in the ability to initiate plans, speak, express emotion, or find pleasure.
  • Disorganized symptoms: Confused and disordered thinking and speech, trouble with logical thinking, and sometimes bizarre behaviour or abnormal movements.

Cognition is another area of functioning that is affected in schizophrenia, leading to problems with attention, concentration, and memory and declining educational performance.

Symptoms of schizophrenia usually first appear in early adulthood and must persist for at least six months for a diagnosis to be made. Men often experience initial symptoms in their late teens or early 20s, while women tend to show first signs of the illness in their 20s and early 30s. More subtle signs may have been present earlier, including troubled relationships, poor school performance, and reduced motivation.

Before a diagnosis can be made, however, a psychiatrist should conduct a thorough medical examination to rule out substance misuse or other neurological or medical illnesses whose symptoms mimic schizophrenia.

Risk Factors

Researchers believe that a number of genetic and environmental factors contribute to causation, and life stressors may play a role in the start of symptoms and their course. Since multiple factors may contribute, scientists cannot yet be specific about the exact cause in each case.

Treatment

Though there is no cure for schizophrenia, many patients do well with minimal symptoms. A variety of antipsychotic medications are effective in reducing the psychotic symptoms present in the acute phase of the illness, and they also help reduce the potential for future acute episodes and their severity. Psychological treatments such as cognitive behavioural therapy or supportive psychotherapy may reduce symptoms and enhance function, and other treatments are aimed at reducing stress, supporting employment, or improving social skills.

Diagnosis and treatment can be complicated by substance misuse. People with schizophrenia are at greater risk of misusing drugs than the general population. If a person shows signs of addiction, treatment for the addiction should occur along with treatment for schizophrenia.

Rehabilitation and Living With Schizophrenia

Treatment can help many people with schizophrenia lead highly productive and rewarding lives. As with other chronic illnesses, some patients do extremely well, while others continue to be symptomatic and need support and assistance.

After the symptoms of schizophrenia are controlled, various types of therapy can continue to help people manage the illness and improve their lives. Therapy and psychosocial supports can help people learn social skills, cope with stress, identify early warning signs of relapse, and prolong periods of remission. Because schizophrenia typically strikes in early adulthood, individuals with the disorder often benefit from rehabilitation to help develop life-management skills, complete vocational or educational training, and hold a job. For example, supported-employment programs have been found to help people with schizophrenia obtain self-sufficiency. These programs provide people with severe mental illness competitive jobs in the community.

For many people living with schizophrenia, family support is particularly important to their health and well-being. It is also essential for families to be informed and support themselves. Organizations such as the Schizophrenia and Related Disorders Alliance of America (SARDAA), Mental Health America (MHA), and the National Alliance on Mental Illness (NAMI) offer resources and support to individuals with schizophrenia and other mental illnesses and their families (see Additional Resources).

Optimism is important, and patients, family members, and mental health professionals need to be mindful that many patients have a favourable course of illness, that challenges can often be addressed, and that patients have many personal strengths that must be recognized and supported.

Related Conditions

Below are brief descriptions of several other mental health disorders with characteristics and symptoms similar to schizophrenia, including delusional disorder, brief psychotic disorder, schizophreniform disorder, and schizoaffective disorder.

Delusional disorder involves a person having false beliefs (delusions) that persist for at least one month. The delusions can be bizarre (about things that cannot possibly occur) or non-bizarre (things that are possible but not likely, such as a belief about being followed or poisoned).

Apart from the delusion(s), it does not involve other symptoms. The person may not appear to have any problems with functioning and behaviour except when they talk about or act on the delusion.

Delusional beliefs can lead to problems with relationships or at work and to legal troubles. Delusional disorder is rare: around 0.2% of people will have it in their lifetime. Delusional disorder is treated with individual psychotherapy, although people rarely seek treatment as they often do not feel they need treatment.

Brief psychotic disorder occurs when a person experiences a sudden short period of psychotic behavior. This episode lasts between one day and one month, and then the symptoms completely disappear, and the person returns to normal.

Brief psychotic disorder involves one (or more) of the following symptoms:

  • Delusions,
  • Hallucinations,
  • Disorganized speech
  • Grossly disorganized or catatonic behaviour.

Although the disturbance is short, individuals with brief psychotic disorder typically experience emotional turmoil or overwhelming confusion. Brief psychotic disorder can occur at any age. However, the average age at onset is the mid-30s. It is twice as common in females than in males.

It is important to distinguish symptoms of brief psychotic disorder from culturally appropriate responses. For example, in some religious ceremonies, an individual may report hearing voices. Still, these do not generally persist and are not perceived as abnormal by most members of the individual’s community.

The symptoms of schizophreniform disorder are similar to those of schizophrenia, but the symptoms only last a short time—at least one month but less than six months. If the symptoms last longer than six months, then the diagnosis changes to schizophrenia.

The schizophreniform disorder involves two or more of the following symptoms, each present for a significant portion of time during one month (or less if successfully treated):

  • Delusions,
  • Hallucinations
  • Disorganized speech,
  • Grossly disorganized behaviour or catatonic behaviour, and
  • Negative symptoms.

A diagnosis of schizophreniform disorder does not require problems in functioning (as schizophrenia does). In the U.S., the schizophreniform disorder is significantly less common than schizophrenia. About one-third of individuals with an initial diagnosis of schizophreniform disorder recover within 6 months, and schizophreniform disorder is their final diagnosis. Most of the remaining two-thirds of individuals will eventually receive a diagnosis of schizophrenia or schizoaffective disorder.

People with schizoaffective disorder experience symptoms of a major mood episode of depression or bipolar disorder (major depression or mania) at the same time as symptoms of schizophrenia (delusions, hallucinations, disorganized speech, grossly disorganized behaviour, or negative symptoms). Symptoms of a major mood episode must be present for the majority of the duration of the active illness, and there must be at least two weeks when delusions or hallucinations are present in the absence of a mood episode.

Schizoaffective disorder is about one-third as common as schizophrenia, affecting about 0.3% of people at some time in their lives. The typical age at onset of schizoaffective disorder is early adulthood, although it can begin anywhere from adolescence to late in life. A significant number of individuals initially diagnosed with another psychotic illness later receive the diagnosis of schizoaffective disorder when the pattern of mood episodes becomes apparent.

Source From psychiatry.org 

FAQs

The earliest signs and symptoms come before a diagnosis can be certain. There is now a growing emphasis on identifying young people at high risk for a psychotic disorder and offering treatment and services in advance of a full psychotic experience. At this stage, symptoms and signs include:

  • Problems with personal relationships and school or work performance.
  • Experiencing odd phenomena such as hearing a voice or noise but being uncertain if it was really heard.
  • Becoming excessively suspicious.

Also, some people may develop a “loner” lifestyle, a sense that something is wrong and that one’s mind is playing tricks, and other things that mark a change in life course. These are not always early schizophrenia symptoms, but it is a good time for clinical assessment and care in hopes of preventing a progression to a full first episode of psychosis.

In the first episode of schizophrenia, common symptoms include paranoia, hearing voices or seeing visions, disorganization of thoughts and behaviours, low motivation and reduced experience of pleasure, anxiety, fear, depression, sleep disturbance, social withdrawal, and sometimes poor emotional control seen as anger and hostility.

All the signs and symptoms can occur at a mild level in people who are not ill. A diagnosis must look at the severity of the symptoms, their impact on function, and resulting distress. It is critical to rule out other possible causes of these symptoms before a diagnosis of schizophrenia.

Substance abuse is a common problem in persons with schizophrenia, including tobacco, marijuana, alcohol, and other drugs. Abuse has all the usual health-related problems, but the presence of schizophrenia complicates this issue. Patients may stop their antipsychotic medications if they believe it interferes with the marijuana or alcohol effect. Disorganized thinking and behaviour may be made worse. Marijuana increases the risk of schizophrenia in vulnerable young people and may complicate the course of schizophrenia. Impaired cognition is common in schizophrenia, and misused drugs adversely affect cognition, such as attention, memory, task orientation, and the like. There are many good reasons to avoid substance misuse.

All persons with schizophrenia need drugs some of the time, and most will do better with continued use of medication to help control symptoms and prevent relapse. However, the drugs are not effective for all aspects of the illness. Cognitive behavioural therapy may help with certain symptoms, and supportive psychotherapy can support personal strengths and improve quality of life. Vocational programs increase the chances of successful employment. Family psychoeducation can give patients and family members a better understanding of the disorder and what will be helpful. A relationship with a case worker may help with the problems of daily living, and supportive psychotherapy may help. New treatments, such as neuromodulation, are being developed, and drugs with novel mechanisms of action are being tested.

So, yes, drug treatment is important, but many patients will not take medication continuously for long periods, and many experience side effects that have to be addressed. An integrated, comprehensive approach works best.

Negative symptoms refer to a decrease or absence of normal experiences/actions. Examples include reduced speech, low drive and motivation, little experience and expression of normal emotions, reduced pleasure in activities, failure to initiate activities, withdrawal from social interaction, and indifference to personal relations.

Warning signs include trouble sleeping, increased anxiety, agitation, increasing suspiciousness or hostility, lack of insight into symptoms, and an increase in severity of any of the person’s usual symptoms. Here, continuity of clinical care is essential to detection and rapid intervention.

Source From psychiatry.org 

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